values of troponin t and myoglobin predictive of non-cardiac ischemia in rats

objective(s):biochemical markers are important for the timely diagnosis and follow-up of ischemic events. most of the markers have been previously studied in the context of cardiac ischemia. however, research on markers of non-cardiac events has been insufficient. therefore, we investigated the relationship between troponin and myoglobin which are commonly used markers of cardiac ischemia, in non-cardiac ischemia. materials and methods: forty-eight rats were equally divided into six groups. group i was the control group. group ii was the sham group and received a simple laparotomy. the superior mesenteric artery was clamped in groups iii and iv in order to create mesenteric ischemia. the left femoral artery was clamped in groups v and vi in order to create peripheral ischemia. intracardiac blood samples were taken from all groups (during the 3rd hour of ischemia in groups iii and v and the 6th hour of ischemia in group iv and vi) and troponin t and myoglobin levels were measured. results: troponin and myoglobin levels were statistically similar in groups i and ii. moreover, increments were detected for troponin and myoglobin in ischemia groups according to group i and ii. furthermore, higher troponin tlevels were detected after three hours of mesenteric ischemia and higher myoglobin values were observed after six hours of mesenteric ischemia (p<0.05). conclusion: troponin t and myoglobin are not specific for non-cardiac ischemia, and they may be useful for detecting other ischemic events.